Today at Doctor’s Choice Pharmacy, a woman came in looking frustrated. She placed her prescription on the counter and sighed. “I don’t understand. My doctor increased my metformin from 1,500 mg to 2,000 mg daily to help with my blood sugar and weight loss, but when I started taking the higher dose, I actually gained 2 to 4 pounds. Then, when I stopped taking it, I lost the weight. What’s going on?”
I nodded, understanding her confusion. “Metformin is well-known for its role in blood sugar control and weight management, but the way it affects weight can vary. Some people lose weight on it, while others notice fluctuations—especially during the first few weeks of a dosage change.”
She frowned. “But why would my weight go up when I was taking more of it?”
“Metformin works by improving insulin sensitivity and reducing the amount of glucose your liver produces,” I explained. “However, when you increase the dose, your body may initially retain more water as it adjusts to the new medication level. That water retention can show up as weight gain, but it’s usually temporary.”
She looked relieved but still had questions. “So, why did I lose the weight again after stopping it?”
“When you stop taking metformin, that temporary water retention may subside,” I said. “However, keep in mind that metformin doesn’t directly cause fat gain—it primarily influences how your body processes glucose. Long-term, it typically helps with weight loss rather than gain.”
She asked, “Should I stay on it, or is there a better option for me?”
“That depends on your overall health goals,” I said. “Metformin is one of the safest and most effective medications for managing prediabetes, type 2 diabetes, and insulin resistance. If weight loss is your primary concern, your doctor might consider adjusting your dose or exploring other medications like GLP-1 receptor agonists, which have a stronger effect on appetite control.”
Before she left, I added, “If you experience side effects like bloating or GI discomfort, we can also compound metformin into a liquid or slow-release form to make it easier on your stomach.”
She smiled. “That’s good to know. I’ll talk to my doctor about my options. Thanks for explaining everything.”
At Doctor’s Choice Pharmacy, we help patients navigate medication adjustments, weight changes, and personalized treatment options. Every patient’s journey is unique, and we’re here to support them every step of the way.
Until tomorrow,
Rania – Your Friendly Pharmacist at Doctor’s Choice Pharmacy
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Phone
(909) 532-5588
Location
639 N 13th Ave , Upland. Ca 91786
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