Daily Diary – Day 79: Understanding Viberzi for IBS

Hello Diary,

Today, Mr. P came in with questions about Viberzi (eluxadoline) and how it compares to other medications for irritable bowel syndrome (IBS). He also wanted to understand why it is considered a controlled medication. Here’s what we discussed.

What is Viberzi?

• Viberzi (Eluxadoline): Viberzi is a medication specifically used to treat IBS with diarrhea (IBS-D). It works by activating receptors in the nervous system that can slow down bowel movements and reduce pain.

How Does Viberzi Work?

• Mechanism of Action: Viberzi is an opioid receptor modulator. It activates certain opioid receptors in the gut, which helps to decrease bowel contractions, reduce fluid secretion into the intestines, and enhance the firmness of stools. This leads to reduced diarrhea and abdominal pain in patients with IBS-D.

Why is Viberzi Considered a Controlled Medication?

• Controlled Substance: Viberzi is classified as a Schedule IV controlled substance. This classification is due to its potential for abuse and dependence because it interacts with opioid receptors, although the risk is considered lower compared to other opioids.
• Monitoring: Due to this classification, Viberzi is monitored more closely, and prescriptions must be carefully managed by healthcare providers.

Comparing Viberzi to Other IBS Medications:

1. Antispasmodics (e.g., Dicyclomine, Hyoscyamine):

   • Use: These medications help relieve muscle spasms in the gut, reducing pain and cramping.
   • Mechanism: They work by relaxing the muscles of the gastrointestinal tract.
   • Effectiveness: Primarily used for general IBS symptoms, not specifically for IBS-D.

2. Antidiarrheals (e.g., Loperamide):

   • Use: Helps control diarrhea by slowing down bowel movements.
   • Mechanism: Works by decreasing the movement of the gut.
   • Effectiveness: Useful for occasional diarrhea, but not targeted for overall IBS management.

3. Bile Acid Sequestrants (e.g., Cholestyramine):

   • Use: Used for diarrhea associated with IBS, especially when bile acid malabsorption is suspected.
   • Mechanism: Binds bile acids in the intestine to prevent them from causing diarrhea.
   • Effectiveness: Can be effective, but may cause side effects like bloating and gas.

4. Alosetron (Lotronex):

   • Use: Specifically for severe IBS-D in women who have not responded to other treatments.
   • Mechanism: Blocks serotonin signals in the gut to reduce diarrhea and abdominal discomfort.
   • Effectiveness: Effective but has a risk of serious side effects like ischemic colitis.

Benefits of Viberzi:

• Targeted Treatment: Specifically designed for IBS-D, providing targeted relief for diarrhea and abdominal pain.
• Dual Action: Combines pain relief and diarrhea control, addressing both major symptoms of IBS-D.

Why Choose Doctor’s Choice Pharmacy?

• Expert Guidance: Our pharmacists provide detailed instructions and answer any questions you may have about your medications.
• Personalized Care: We offer advice tailored to your specific health needs and medication regimen.
• Convenient Services: Enjoy free delivery and shipping across California, ensuring you get your medications quickly and easily.

Mr. P left feeling informed about how Viberzi compares to other IBS medications and why it is considered a controlled substance. He appreciated the comprehensive explanation and personalized care we provide.

Until tomorrow, Rania – Your Friendly Pharmacist at Doctor’s Choice Pharmacy

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