Today at Doctor’s Choice Pharmacy, we received a prescription from a women’s health provider for a custom-compounded Fluconazole 2% vaginal cream. Shortly after, the provider gave us a quick call to clarify,
“Hi Rania, this is for a recurrent yeast infection case. Oral fluconazole hasn’t worked well—can we make it into a vaginal cream instead?”

I said, “Absolutely. We compound Fluconazole vaginal cream at 2%, and it’s a great alternative when oral therapy either isn’t effective or isn’t tolerated. Direct application delivers the antifungal medication right to the site of infection, which can mean faster and more targeted relief.”

She replied, “Exactly what I’m going for. She’s had side effects with oral treatment.”

I added, “This route also avoids the first-pass metabolism through the liver, which can be helpful for patients with sensitivity or GI side effects. It’s often used in cases of:
✔ Recurrent vulvovaginal candidiasis
✔ Resistant yeast infections
✔ Patients unable to tolerate oral meds”

She asked, “How long is the usual course?”

“We typically compound a 7-day supply, applied once daily at bedtime. The cream comes with a prefilled applicator or reusable one—whichever is preferred,” I said. “It’s gentle, effective, and compounded with a clean base that avoids added fragrances or dyes.”

Before hanging up, she added, “Thanks Rania. I’m glad you can offer this—it really makes a difference for my sensitive patients.”

And that’s why we do what we do at Doctor’s Choice Pharmacy—to make sure every patient has options when standard treatments fall short.

Until tomorrow,
Rania – Your Friendly Pharmacist at Doctor’s Choice Pharmacy

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